… twelfth to be described in 1989 was Interleukin-12 (IL-12). In … The pathogenetic relevance of
such immune cell homing has … Crohn's disease LP cells manifest increased secretion of IFN-…

… alpha4beta7 (vedolizumab) and interleukin 12 (IL12) and … Th1/Th2 paradigm offered a
framework for understanding the pathogenesis of IBD and several other chronic inflammatory …

… All relevant papers describing the incidence and pathogenesis of … by inducing and maintaining
a Th1 response [Citation20]. IL-12 is … As a consequence of the perceived increased risk of …

… A subset of IBD-relevant human enteric bacterial species preferentially stimulates bacterial
antigen-specific Th1 and Th17 immune responses in this model, independent of luminal and …

… of interleukin-12related cytokine transcripts in inflammatory … contribute to the pathogenesis
of Crohn disease via IL-23/IFN-… Th1/Th17 immune response is induced by mesenteric lymph …

… The cytokines interleukin-12 (IL-12) and IL-23 share a … in the pathogenesis of IBD [73],
and therefore, therapies targeting … baseline or <150 in the Crohn's Disease Activity Index (CDAI) …

… , Interleukin-12 (IL-12) features in inflammation regulation and anti-bacterial immunity. … 12
contributes to early adaptive immune responses in vertebrates remain incompletely understood…

… our understanding of Crohn’s disease (CD) pathogenesis. This … starts as a pure, Th1-mediated,
immunologic response that is … with Crohn's disease: role of CARD15 3020insC mutation? …

… IL23R) or the Th1/IL-35 pathway as the consequence of their … of these disease associated
gene loci in disease pathogenesis … Crohn Disease. Am J Hum Genet 2009; 84: 399-405. 17. …

… They both belong to the interleukin 12 family and are related … +IL23R + T cells that produce
Th1 and Th17 cytokines. Citation… Slowly, we begin to understand the complex pathogenesis, …